The complete guide to tirzepatide for weight loss

Tirzepatide is a first-in-class dual GIP/GLP-1 receptor agonist, branded as Mounjaro (for diabetes) and Zepbound (for weight loss). It's the most effective weight loss medication available today.

In the SURMOUNT-1 trial, patients lost an average of 22.5% of body weight — significantly more than semaglutide.

Tirzepatide activates two hormones instead of one:

• **GLP-1:** Reduces appetite and slows digestion (same as semaglutide)
• **GIP (Glucose-dependent Insulinotropic Polypeptide):** Additional metabolic benefits including improved fat metabolism and insulin sensitivity

This dual action typically produces faster and greater weight loss results.

• **Weeks 1-4:** 2.5mg weekly
• **Weeks 5-8:** 5mg weekly
• **Weeks 9-12:** 7.5mg weekly
• **Weeks 13-16:** 10mg weekly
• **Week 17+:** 12.5-15mg weekly (maximum)

Dose escalation is slower than semaglutide to ensure tolerability.

Tirzepatide typically produces superior results:

• **Month 1:** 4-7 lbs lost
• **Month 3:** 15-22 lbs lost
• **Month 6:** 30-45 lbs lost
• **Month 12:** 45-70+ lbs lost

The SURMOUNT trials showed 1 in 3 patients lost over 25% of their body weight.

Similar to semaglutide with generally comparable tolerability:

• Nausea (usually mild, improves with dose adjustment)
• Decreased appetite
• Diarrhea or constipation
• Injection site reactions

Your TrimDoctor physician manages side effects through dose titration and supportive care.

• **Brand (Zepbound/Mounjaro):** $1,000-1,200/month without insurance
• **TrimDoctor compounded:** Starting at **$249/month**

TrimDoctor makes tirzepatide accessible through compounded formulations from licensed 503B pharmacies.